The break from domestic football gave The Reds a much-needed revitalisation in resources as Klopp welcomed the visitors with only Andrew Robertson being the notable absentee. Jordan Henderson joined the midfield ranks, and Fabio Carvalho was initiated on the left as Firmino and Salah joined him in attack.
Roberto De Zerbi marked his debut as Brighton & Hove Albion head coach with a point at Anfield as his side played out a thrilling 3-3 draw with Liverpool.
The Italian looked set for a dream start as Seagulls boss when his team raced into a two-goal first-half lead thanks to Leandro Trossard.
However, goals in either half from Roberto Firmino. One requiring a VAR check to overturn an offside call dragged the Reds back level.
And they appeared set for a much-needed win after forcing Adam Webster to put through his own net from a corner to complete the comeback.
However, Trossard smashed in another fine finish six minutes from time at the Kop end to earn a deserved draw for the visitors.
Both managers resisted holding out for the draw and pushed for a fourth goal for the rest of the match. A 30-yard free-kick from Alexander Arnold almost found the winner, but a brilliant flick of the wrist from Sanchez kept the tie level.